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Nancy Guthrie vanished from her Catalina Foothills home near Tucson, Arizona, in the early hours of February 1, 2026, after being dropped off by her son-in-law Tommaso Cioni following a family dinner at Annie’s residence. Authorities, including the Pima County Sheriff’s Office and FBI, have treated the case as a suspected kidnapping for ransom since Day 1, citing blood on the porch (confirmed as Nancy’s), a disabled doorbell camera, and her pacemaker monitor losing connection around 2:28 a.m. No forced entry was evident, pointing to someone familiar with the home.