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A Recent Study Led by Researchers at USC Found That Type 2 Diabetes May Be Reversible in Surprising Ways

In a groundbreaking discovery, researchers at the University of Southern California (USC) have uncovered new evidence that could reshape how we understand and treat type 2 diabetes. Long believed to be a chronic, progressive condition, this latest study suggests that reversing type 2 diabetes may be more achievable than previously thought—and it doesn’t always require medication.

Here’s what the study found, what it means for patients, and the potential future of diabetes care.

The Study at a Glance

Conducted by a team at the USC Leonard Davis School of Gerontology, the research focused on metabolic flexibility—the body’s ability to switch between burning carbohydrates and fat for energy.

Key Findings:

• Dietary changes alone may reverse type 2 diabetes in some patients.
• Periodic fasting (or a fasting-mimicking diet) showed promising results in lowering blood sugar, improving insulin sensitivity, and reducing dependence on medication.
• Participants in the study who followed structured dietary interventions saw improvements in key biomarkers, including fasting glucose, HbA1c, and triglycerides.
• Some patients maintained these improvements even after returning to a regular diet.

How Is This Possible?

The research supports the idea that targeted lifestyle changes—especially those that reduce visceral fat (the harmful fat around organs)—can help retrain the body to manage glucose more efficiently.

Mechanisms at Work:

• Reduced insulin resistance: By lowering fat in the liver and pancreas, the body responds better to insulin.
• Cellular regeneration: Fasting periods may trigger the regeneration of insulin-producing cells in the pancreas.
• Improved metabolic pathways: Shifting the body away from constant glucose intake allows it to reset and improve its response to sugar.
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