HT15. COVID-19 vaccinated individuals may be ill…See more

The connection to myocarditis seemed plausible for several reasons. The condition disproportionately affects males, and estrogen is known to have anti-inflammatory effects. Genistein, which mimics estrogen only weakly, might offer some of those protective benefits without the hormonal side effects of stronger compounds.

Wu’s team ran a parallel series of experiments in which cells, cardiac spheroids, and mice were pretreated with genistein before being exposed to the vaccine or the CXCL10 and IFN-gamma combination. In each case, genistein significantly reduced the damaging effects on heart tissue.